홈페이지 최상단으로 이동

변희국 교수님

  • 전공 : 해양생물신소재공학
  • 직급 : 교수
  • 연구실 : N17-308-1호
  • 전화번호 : 033-640-2854
  • 이메일 : hgbyun@gwnu.ac.kr
  • 연구분야 : 해양생물신소재공학

학력

부산수산대학교 응용화학과 이학사 부산수산대학교 응용화학과 이학석사 부경대학교 화학과 이학박사

경력

현재. 강릉원주대학교 해양생물공학과 부교수 현재. 강릉원주대학교 동해안해양바이오창조인재양성사업단 단장 강릉원주대학교 농수산인교육원장 University of British Columbia(UBC), Canada, Visiting Professor 해양생명공학부 학부장 해양생명공학부 해양생물공학전공 주임교수 마린바이오21 해양바이오프로세스연구단 연구교수

한국식품공업협회 한국식품연구소 연구원 한국학술진흥재단 박사후과정 연구원 한국과학재단 신진연구원 Marine Biotechnology Institute(MBI), Japan, Post-Doc. 수산과학연구소 특별연구원 부산수산대학교 화학과 조교

전문연구분야

해양생물자원 유래의 항고혈압 및 항산화성 물질 탐색 및 개발 해양생물자원 유래의 항암 및 항치매 물질 탐색 및 개발 해양미생물 유래의 신기능성 생물신소재 개발 해양천연물의 분리정제 및 구조해석 Lipase에 의한 어유의 기능성 개선 Membrane bioreactor를 이용한 연속적 대량 생산기술 개발

주요논문 - 국외전문학술지

Byun H.G., J.K. Lee. Hepatoprotective effect of a phase II enzyme inducer from chlorella extract on alcohol induced hepatotoxicity in rats. Journal of Medicinal Food. In press (2014). Lee J.K., L.C. Eunice, H.G. Byun. Characterization of β‑secretase inhibitory peptide purified from skate skin protein hydrolysate. European Food Research and Technology, In press (2014). Kim S.R., T.K. Eom, H.G. Byun. Inhibitory effect of the carnosine-gallic acid synthetic peptide on MMP-2 and MMP-9 in human fibrosarcoma HT1080 cells. Journal of Peptide Science 20, 716-724 (2014). Phama M. A., H.G. Byun, K.D. Kim, S.M. Lee. Effect of dietary carotenoid source and level on growth, skin pigmentation, antioxidant activity and chemical composition of juvenile olive flounder Paralichthys olivaceus. Aquaculture 431, 65-72 (2014). Ngo D.H., K.H. Kang, W.K. Jung, H.G. Byun, S.K. Kim. Protective effects of peptides from skate(Okamejei kenojei) skin gelatin against endothelial dysfunction. Journal of Functional Foods 10, 243-251 (2014). Lee J.K., J.K. Jeon, H.G. Byun, Antihypertensive effect of novel angiotensin I converting enzyme inhibitory peptide from chum salmon (Oncorhynchus keta) skin in spontaneously hypertensive rats. Journal of Functional Foods 7, 381-389 (2014). Eom T.K., B.M. Ryu, S.H. Lee, H.G. Byun, Y.I. Park, S.K. Kim, Beta-secretase inhibitory activity of phenolic acid conjugated chitooligosaccharides. J. Enzyme Inhibition and medicinal Chemistry 28, 214-217 (2013). Ko S.C., J.K.Lee, H.G. Byun, S.C. Lee, Y.J. Jeon. Purification and characterization of angiotensin I-converting enzyme inhibitory peptide from enzymatic hydrolysates of Styela clava flesh tissue. Process Biochemistry 47, 34-40(2012). Ko S.C., J.K.Lee, H.G. Byun, S.C. Lee, Y.J. Jeon. Nitric oxide-mediated vasorelaxation effects of anti-angiotensin I-converting enzyme (ACE) peptide from Styela clava flesh tissue and its anti-hypertensive effect in spontaneously hypertensive rats.). Food Chemistry 134, 1141-1145 (2012). Ko S.C., M.C.Kang, J.K. Lee, H.G. Byun, S.K. Kim, S.C. Lee, B.T. Jeon, P.J. Park, W.K. Jung, Y.J. Jeon. Effect of angiotensin I-converting enzyme (ACE) inhibitory peptide purified from enzymatic hydrolysates of Styela plicata. European Food Research and Technology 233, 915-922 (2011). Lee W.S., J.K. Jeon and H.G. Byun, Characterization of novel antioxidative peptide from sand eel, Hypoptychus dybowskii. Process Biochemistry 46, 1207-1211 (2011). Lee J.K., J.K. Jeon and H.G. Byun, Effect of angiotensin I converting enzyme inhibitory peptide purified from skate skin hydrolysate. Food Chemistry 125, 495-499 (2011). Kong, C.S., J.A. Kim, H.G. Byun and S.K. Kim, Anti-obesity effect of carboxymethyl chitin by AMPK and aquaporin-7 pathways in 3T3-L1 adipocytes. J. Nutritional Biochemistry 22, 276-281 (2011). Eom, T.K., C.S. Kong, H.G. Byun, W.K. Jung and S.K. Kim, Lipase catalytic synthesis of diacylglycerol from tuna oil and its anti-obesity effect in C57BL/6J mice. Process Biochemistry 45, 738-743 (2010). Lee, J.K., M.S. Lee, H.G. Park, S.K. Kim and H.G. Byun, Angiotensin I converting enzyme inhibitory peptide extracted from freshwater zooplankton. J. Medicinal Food 13(2), 357-363 (2010). Lee, J.K., J.H. Yun, J.K. Jeon, S.K. Kim and H.G. Byun, Effect of antioxidant peptide isolated from Brachionus calyciflorus. J. Kor. Soc. Appl. Biol. Chem. 53(2), 192-197 (2010). Kong, C.S., J.A. Kim, B. Ahn., H.G. Byun., S.K. Kim, Carboxymethylations of chitosan and chitin inhibit MMP expression and ROS scavenging in human fibrosarcoma cells. Process Biochemistry 45, 179-186 (2010). Lee, J.K., S.H. Hong, J.K. Jeon, S.K. Kim, and H.G. Byun, Purification and characterization of angiotensin I converting enzyme inhibitory peptides from the rotifer, Brachionus roturndiformis. Bioresource Technology 100, 5255-5259 (2009). Byun, H.G., J.K. Lee, H.G.Park, J.K.Jeon, and S.K.Kim, Antioxidant peptides isolated from the marine rotifer, Brachionus roturndiformis. Process Biochemistry. 44, 842-846 (2009). Jung, W.K., S.J. Heo, Y.J. Jeon, C.M. Lee, Y.M. Park, H.G. Byun, Y.H. Choi, S.G. Park, and I.W. Choi, Inhibitory effects and molecular mechanism of dieckol isolated from marine brown alga on COX-2 and iNOS in microglial cells. J. Agric. Food. Chem. 57, 4439-4446 (2009). Je, J.Y., Z.J. Qian, S.H. Lee, H.G. Byun and S.K. Kim, Purification and antioxidant properties of bigeye tuna (Thunnus obesus) dark muscle peptide on free radical-mediated oxidative systems. J. Med. Food 11(4), 629-637 (2008). Byun, H.G., T.K. Eom, W.K. Jung and S.K. Kim, Characterization of fish oil extracted from fish processing by-products. J. Food Sci. Nutr. 13, 7-11 (2008). Qain, Z.J., W.K. Jung, H.G. Byun and S.K Kim, Protective effect of an antioxidative peptide purified from gastrointestinal digests of oyster, Crassostrea gigas against free radical induced DNA damage. Bioresource Technology 99(9), 3365-3371 (2008). Byun, H.G, T.K. Eom, W.K. Jung, F. Shahidi and S.K. Kim, Lipase catalyzed production of monoacylglycerols by esterification of fish oil fatty acids with glycerol. Biotechnology Bioprocess Engineering 12, 491-496 (2007). Byun, H.G., T.K. Eom, W.K. Jung and S.K. Kim, Lipase-catalyzed hydrolysis of fish oil in an optimum emulsion system. Biotechnology Bioprocess Engineering 12, 484-490 (2007). Qian, Z.J., W.K. Jung, S.H. Lee, H.G. Byun and S.K. Kim, Antihypertensive effect of a angiotensin I-converting enzyme inhibitory peptide from bullfog (Rana catebeiana Shaw) muscle protein in spontaneously hypertensive rats. Process Biochemistry 42, 1443-1448 (2007). Jung, W.K., Z.J. Qian, S.H. Lee, S.Y. Choi, N.J. Sung, H.G. Byun and S.K. Kim, Free radical scavenging activity of a novel antioxidative peptide isolated from in vitro gastrointestinal digests of Mytilus coruscus. J. Medicinal Food 10, 197-202 (2007). Je, J.Y., Z.J. Qian, H.G. Byun and S.K. Kim, Purification and characterization of an antioxidant peptide obtained from tuna backbone protein by enzymatic hydrolysis. Process Biochemistry 42, 840-846 (2007). Kim, M.M., V.T. Quang, E. Mendis, N. Rajapakse, W.K. Jung, H.G. Byun, Y.J. Jeon, and S.K. Kim, Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity. Life Sciences 79, 1436-1443 (2006). Byun, H.G., Y.T. Kim, P.J. Park, X. Lin, and S.K. Kim, Chitooligosaccharides as a novel beta-secretase inhibitor. Carbohyd. Polym. 61, 198-202 (2005). Jung, W.K., P.J. Park, H.G. Byun, S.H. Moon, and S.K. Kim, Preparation of hoki (Johnius belengerii) bone oligophosphopeptide with a high affinity to calcium by carnivorous intestine crude proteinase. Food Chem. 91, 333-340 (2005). Je, J.Y., P. J., Byun, H. G., Jung, W. K. and Kim, S. K. Angiotensin I converting enzyme inhibitory peptide derived from fermented mussel, Mytilus edulis. Bioresource Technology 96(14), 1624-1629 (2005). Rajapakse, N., E. Mendis, H.G. Byun and S.K. Kim, Purification and in vitro antioxidative effects of giant squid muscle peptides on radical mediated oxidative systems. J. Nutr. Biochem. 16, 562-569 (2005). Mendis, E., N. Rajapakse, H.G. Byun and S.K. Kim, Investigation of jumbo squid (Dosidicus gigas) skin gelatin peptides for their In vitro antioxidant effects. Life Sciences 77, 2166-2178 (2005). Kim, S.K., Park, P. J., Jung, W.K., Byun, H.G., Mendis, E. Cho, Y.I. Inhibitory Activity phosphorylated chitooligosaccharides on the formation of calcium phosphate. Carbohyd. Polym. 60, 483-487 (2005). Park, P.J., S.J. Heo, E.J. Park, S.K. Kim, H.G. Byun, B.T. Jeon, Y.J. Jeon, Reactive oxygen scavenging effect of enzymatic extracts from Sargassum thunbergii. J. Agric. Food Chem. 53, 6666-6672 (2005). Park, P.J., J.Y. Je, H.G. Byun, S.H. Moon and S.K. Kim, Antimicrobial activity of hetero-chitosans and their oligosaccharides with different molecular weights. J. Microbial. Biotech. 14(2), 317-323 (2004). Byun, H.G., H. Zhang, K. Adachi, Y. Shizuri, W.J. Lee and S.K. Kim, Novel antifungal topiperazine from marine fungus. J. Antibiotics, 56(2), 102-106 (2003). Kim, S.K., P.J. Park, H.G. Byun., J.Y. Je, S.H. Moon and S.H. Kim, Recovery of fish bone from hoki(Johnius belengeri) frame using a proteolytic enzyme isolated from mackerel intestine. J. Food Biochem. 27, 255-266 (2003). Byun, H.G., P.J. Park, N.J. Seong and S.K. Kim, Purification and characterization of a serine proteinase from the tuna pyloric caeca. J. Food Biochem., 26, 479-494 (2003). Byun H.G. and S.K. Kim, Structure and activity of angiotensin I converting enzyme inhibitory peptides derived form Alaskan pollack skin. J. Biochem. Mol. Biol., 35, 234-241 (2002). Park, P.J., S.H. Lee, H.G. Byun, S.H. Kim, S.H. Lee and S.K. Kim, Purification and characterization of a collagenase from the mackerel, Scomber japonicus. J. Biochem. Mol. Biol. 35(6), 576-582 (2002). Park, P. J., J. Y. Chung, H. G. Byun, D. H. Seog and S. K. Kim, Molecular cloning of a pore-forming subunit(Kir6.2 Gene) of the ATP-sensitive potassium channel in the Bullfrog, Rana catesbeiana shaw. Biosci. Biotechnol. Biochem., 66(10), 2279-2282 (2002). Byun, H. G. and S. K. Kim, Purification and characterization of angiotensin I converting enzyme (ACE) inhibitory peptides from Alaska pollack (Theragra chalcogramma) skin. Process Biochem., 36, 1155-1162 (2001). Kim, S.K., Y.T. Kim, H.G. Byun, P.J. Park and H. Ito, Purification and characterization of antioxidative peptides from bovine skin. J. Biochem. Mol. Biol., 34(3), 219-224 (2001). Kim, S.K., H.G. Byun, P.J. Park and F. Shahidi, Angiotensin I converting enzyme inhibitory peptides purified from bovine skin gelatin hydrolysate. J. Agric. Food Chem., 49(6), 2992-2997 (2001). Kim, S.K., Y.T. Kim, H.G. Byun, K.S. Nam, D.S. Joo and F. Shahidi, Isolation and characterization of antioxidative peptides from gelatin hydrolysate of alaska pollack skin. J. Agric. Food Chem., 49(4), 1984-1989 (2001). Jeon, Y.J., H.G. Byun and S.K. Kim, Improvement of functional of cod frame protein hydrolysates using ultrafiltration membranes. Process Biochem., 35, 471-478 (2000). Kim, S.K, Y.J. Jeon and H.G. Byun, Enzymatic recovery of cod frame protein by crude proteinase from tuna pyloric caeca. Fish. Sci., 63(3), 421-427 (1997).

주요논문 - 국내전문학술지

Lee J.K. and H.G. Byun. Induction effect of Quinone Reductase by Carboxymethyl-Chitosan and -Chitooligosaccharide in Hepatoma Cell. Journal of Chitin and Chitosan 19(1), 34-39 (2014). Kim S.R. and H.G. Byun. The Novel Angiotensin I Converting Enzyme Inhibitory Peptide from Rainbow Trout Muscle Hydrolysate. Fisheries and Aquatic Sciences 15(3), 183-190 (2012). Lee J.K., Z.J. Qian and H.G. Byun. Antioxidant activity of carboxymethylated chitooligosaccharide. Journal of Chitin and Chitosan 17(1), 30-36 (2012). Lee J.S., H.G. Byun and J.K. Jeon. Comparison of Xenobiotic Metabolism and Antioxidative Status in Cultivated and Stocked Rockfish Sebastes schlegeli. Kor J Fish Aquat Sci 45(2), 97-103 (2012). Lee, W.S., Kim, Y.T. and H.G. Byun, Antioxidant activities of steamed extract from squid (Todarodes pacificus) muscle. J. Food Sci. Nutr. 16, 127-134 (2011). Lee, J.K., M.S. Lee, S.K. Kim and H.G. Byun, Synthesis and emulsifying activity of carboxymethyl chitosan. J. Chitin Chitosan 16, 65-70 (2011). Lee, J.K., J.K. Jeon and H.G. Byun, Purification of angiotensin I converting enzyme inhibitory peptide from squid skin. Kor J Fish Aquat Sci 44(2), 118-125 (2011). Park, S.H., J.K. Lee, J.K. Jeon and H.G. Byun, Characterization of a collagenase-1 inhibitory peptide purified from skate Dipturus chilensis skin. Kor J. Fish Aquat Sci 44(5), 456-463 (2011). Kim, K.D., J.Y Seo, S.H. Hong, J.H. Kim, H.G. Byun, K.W. Kim, M.H. Son, and S.M. Lee, Effects of dietary inclusion of various additives on growth performance Hematological parameters, fatty acid composition, gene expression and histopathological changes in juvenile olive flounder paralichthys olivaceus. Kor J Fish Aquat Sci 44(2), 141-148 (2011). Lee, J.K, S.K Kim and H.G. Byun, Characterization of fatty acid extracted from Brachionus rotundiformis using lipase-catalyzed hydrolysis. J. Fish. Sci. Technol. 12(1), 16-23 (2009) Je, J.Y., H.G. Byun and S.K. Kim, Prolyl endopeptidase inhibitory activity of sulfated carboxymethyl chitin. J. Chitin Chitosan 10, 79-81 (2005) Byun H. G. and S. K. Kim, Trend and prospect of marine bioindustry. Food Industry and Nutrition 10, 32-39 (2005) (review). Park, P.J., J.Y. Je, W.K. Jung, H.G. Byun, and S.K. Kim, Free radical scavenging activities of chitooligosaccharides hydrolyzed from chitosan with high degree of deacetylation on 1,1-Diphenyl-2-picrylhydrazyl radical. J. Chitin Chitosan. 9(3), 108-113 (2004). Byun, H.G., J.Y. Je, and S.K. Kim, Preparation and characterization of leather-like material from shark intestines, J. Fish. Sci. Technol., 5, 136-140 (2002) Byun, H.G., and S.K. Kim, Fungicidal activity against pyricularia oryzae of substance purified from marine fungus metabolites, J. Fish. Sci. Technol., 5,97-102 (2002) Byun, H.G., S.Y. Jeong, Y.T. Park, W.J. Lee and S.K. Kim, Algicidal activity against Cochlodinium polykrikoides of substance purified from marine bacteria metabolites, J. Fish. Sci. Technol., 5, 150-155 (2002) Kim, S.K., P.J. Park and H.G. Byun, Continuous citric acid production of dairy wastewater using immobilized Aspergillus niger, Biotechnol. Bioprocess Eng., 7, 89-94 (2002) Kim, S.K., H.G. Byun, P.J. Park, and K. Adachi, Purification and structure of antioxidative substance derived from Tetraselmis suecica, J. Korean Fish. Soc., 35, 155-161 (2002) Kim, S.K., H.C. Baek, H.G. Byun, O.J. Kang and J.B. Kim, Biochemical composition and antioxidative activity of marine microalgae, J. Korean Fish. Soc. J. Korean Fish. Soc. 34(3), 260-267 (2001). Kim, S.K., H.G. Byun, H.C. Baek, O.J. Kang and J.B. Kim, Structure and isolation of antioxidative substance derived from Phaeodactylum tricornutum, J. Korean Fish. Soc. 34(5), 556-562 (2001). Kim, S.K., Y.J. Jeon, W.S. Kim, H.C. Back, P.J. Park, H.G. Byun and S.C. Bai, Biochemical composition of marine microalgae and their potential antimicrobial activity, J. Fish. Soc. Tech. 4(2), 75-83 (2001). Byun, H.G. and S.K. Kim, Improvements of functional properties of fish oil and their application. Aquatic Industry Science Research 15, 27-42 (2001). Byun, H.G., P.J. Park and S.K. Kim, Preparation and characterization of emulsion using carboxymethylchitin, J. Chitin Chitosan 6(3), 7-13 (2001). Kim, S.K. and H.G. Byun, Application of membrane separation technology in seafood industry, Korean Membrane J., 10, 163-174, (2000)(Review) Choi, J.H., H.G. Byun and S.K. Kim, Hydrolysis of fish protein concentration in an ultrafiltration membrane reactor, Korean Membrane J. 10, 83-91 (2000). Choi, Y.R. P.J. Park, J.H. Choi, H.G. Byun, I.C. Jeong, S.H. Moon and S.K. Kim, Purification and characterization of angiotensin I converting enzyme inhibitory peptides from enzymatic hydrolysate of cod liver protein, Korean Journal of Life Science 10, 140-149 (2000). Kim, S.K., Y.J. Jeon, H.G. Byun and P.J. Park, Calcium absorption acceleration effect on phosphorylated and nonphosphorylated peptides from hoki (Johnius belengeri) frame. J. Korean Fish. Soc. 32(6), 713-717 (1999). Kim, S.K., H.G. Byun, and Y.J. Jeon, Continuous hydrolysis of tuna boiled extract using proteinase from tuna pyloric caeca in membrane reactor, J. Korean Fish. Soc., 32(2), 127-133 (1999). Kim, S.K., H.G. Byun, and Y.J. Jeon, Desalination of tuna boiled extract by electrodialysis, J. Korean Fish. Soc., 32(1), 68-74 (1999) Kim, S.K., H.G. Byun, Y.J. Jeon, D.S. Ju, and J.B. Kim, Development of natural seasoning using desalinated tuna boiled extract, J. Korean Fish. Soc., 32(1), 75-82 (1999) Jeon, Y.J., B.J. Lee, H.G. Byun, J.B. Kim, and S.K. Kim, Recovery of protein hydrolysate from hoki(Johnius belengeri) frame with tuna pyloric ceca crude enzyme and its functionalities, J. Korean Soc. Agric. Chem. Biotechnol., 42(1), 49-57 (1999) Choi, J.S., C.K. Lee, Y.J. Jeon, H.G. Byun, and S.K. Kim, Properties of the ceramic composites and glass-ceramics prepared by using the natural hydroxyapatite derived from tuna bone, J. of Kor. Ind. & Eng. Chem., 10(3), 394-399 (1999). Jeon, Y.J., B.J. Lee, H.G. Byun, P.J. Park and S.K. Kim, Improvement of the functionalities by phosphorylation of Hoki(Johnius belengeri) frame protein hydrolysates, J. Korean Soc. Agric. Chem. Biotechnol., 42(2), 128-133 (1999) Kim, S.K., J.S. Choi, C.K. Lee, H.G. Byun, Y.J. Jeon, E.H. Lee, and I.Y. Park, Synthesis and biocompatibility of the hydroxyapatite ceramic composites from tuna bone(Ⅲ) - The bonding properties between hydroxyapatite ceramics composites in the simulated body fluid, J. of Kor. Ind. Eng. Chem., 9(3), 322-329 (1998). Jeon, Y.J., P.J. Park, H.G. Byun, B.K. Song, and S.K. Kim, Production of chitosan oligosaccharides using chitin-immobilized enzyme, Korean J. Biotechnol. Bioeng. 13(2), 147-154 (1998) Byun, H.G., Y.J. Jeon and S.K. Kim, Characteristics on the permeation of protein through membrane of ultrafiltration reactor, Membrane J. 8(1), 42-49 (1998) Kim, G.H., Y.J. Jeon, H.G. Byun, Y.S. Lee, and S.K. Kim, Effect of calcium compounds from oyster shell bound fish skin gelatin peptide in calcium deficient rats, J. Korean Fish. Soc. 31(2), 149-159 (1998). Kim, G. H., Y.J. Jeon, H.G. Byun, P.J. Park and S.K. Kim, Purification and characterization of beta-galactosidase from sea urchin, Hemicentrotus pulcherrimus. J. Kor. Fish. Soc., 31(5), 637-644 (1998). S.K., O.J. Kang, H.G. Byun, Y.J. Jeon, and J.B. Kim, Purification and characterization of carotenoprotein from the muscle of Ascidian, Halocynthia roretzi. Agricultural Chemistry and Biotechnology 41(1), 31-41, (1998) Jeon, Y.J., P.J. Park, H.G. Byun, B.K. Song, W.S. Kim, H.P. Yang, and S.K. Kim, Preparation of an immobilized enzyme for enhancing thermostability of the crude proteinase from fish intestine, Korean Soc. Life Sci., 8(6), 627-637, (1998). Lee, C.K., J.S. Choi, Y.J. Jeon, H.G. Byun, and S.K. Kim, The properties of natural hydroxyapatite isolated from tuna bone, J. Korean Fish. Soc., 30(4), 652-659(1997). Choi, J.S., C.K. Lee, H.G. Byun, Y.J. Jeon, E.H. Lee and S.K. Kim, Synthesis and biocompatibility of the hydroxyapatite ceramic composites from tuna bone(Ⅰ) - The sintering properties of hydroxyapatite and hydroxyapatite containing wollastonite crushed with dry milling process -, J. of Kor. Ind. & Eng. Chem., 8(6), 994-999(1997). Choi, J.S., C.K. Lee, H.G. Byun, Y.J. Jeon, E.H. Lee, S.K. Kim, Synthesis and biocompatibility of the hydroxyapatite ceramic composites from tuna bone(Ⅱ)-The sintering properties of hydroxyapatite treated with wet milling process -, J. of Kor. Ind. & Eng. Chem., 8(6), 1000-1005(1997). Kim, S.K., H.C. Lee, H.G. Byun, and Y.J. Jeon, Isolation and characterization of antioxidative peptides from enzymatic hydrolysates of Yellofin Sole skin gelatin, J. Kor. Fish. Soc., 29(2), 246-255(1996). Kim, S.K., H.S. Roh, H.G. Byun, and Y.J. Jeon, Citric acid production from concentrate milk-wastewater by Aspergillus niger, Kor. J. Life Science. 6(1), 6-13(1996). Kim, S.K., Y.J. Jeon, H.G. Byun, and C.B. Ahn, Development of natural seasoning from Alaska Pollack skin gelatin using continuous three-step membrane reactor, Kor. J. Biotech. Bioeng., 10(5), 510-517(1995). Kim, S.K., H.G. Byun, Y.J. Jeon, C.B. Ahn, D.J. Cho, and E.H. Lee, Functional properties of produced fish skin gelatin hydrolysate in a recycle three-step membrane reactor, J. of Kor. Ind. & Eng. Chem., 6(6), 984-996 (1995). Kim, S.K., H.G. Byun, Development of optimum process for continuous hydrolysis of fish skin gelatin using a three-step recycle membrane reactor, J. of Kor. Ind. Eng. Chem., 5(4), 681-697 (1994). Kim, S.K., H.G. Byun, H.G. Lee, and J.H. Ha, Effects of fouling on permeate flux during ultrafiltration of protein solutions in a hollow-fiber membrane reactor, Kor. J. Biotech. Bioeng., 9(5), 483-491(1994). Kim, S.K., H.G. Byun, and E.H. Lee, Optimum extraction conditions of gelatin from fish skins and its physical properties, J. of Kor. Ind. Eng. Chem., 5(3), 547-559(1994). Kim, S.K., H.G. Byun, Y.J. Jeon, H.P. Yang, and D.J. Cho, Continuous production of fish skin gelatin hydrolysates using a two-stage membrane reactor, Kor. Agric. Chem. and Biotech., 37(2), 130-141(1994). Kim, S.K., H.G. Byun, Y.J. Jeon, and D.J. Cho, Functional properties of fish skin gelatin hydrolysate from a continuous two-stage membrane reactor, Kor. Agric. Chem. and Biotech., 37(2), 85-93(1994). Kim, S.K., H.G. Byun, K.D. Choi, H.S. Rho, W.H. Lee, and E.H. Lee, Removal of skin from filefish using enzyme, Bull. Korean Fish. Soc., 26(2), 159-172(1993). Kim, S.K., H.G. Byun, T.J. Kang, and D.J. Song, Enzymatic hydrolysis of yellowfin sole skin gelatin in a continuous hollow fiber membrane reactor, Bull. Korean Fish. Soc., 26(2), 120-132(1993). Byun, H.G., O.J. Kang, and S.K. Kim, Syntheses of the derivatives of chitin and chitosan, and their physicochemical properties, J. Korean Agric. Chem. Soc., 35(4), 265-271(1992). Kim, S.K., H.G. Byun, and M. Cheryan, Continuous hydrolysis of cod skin gelatin in an ultrafiltration reactor, Korean J. Biotechnol. Bioeng. 6(3), 309-319(1991).

저서

Lee J.K., L.C. Eunice, J.K. Jeon, H.G. Byun. Development of Functional Materials from Seafood By-products by Membrane Separation Technology. In Seafood Processing By-Products, p.35-62, Ed. Se-Kwon Kim, Springer (2014) 변희국외 (공역) 대학화학의 기초 (제14판) 자유아카데미 출판사 (2014) 변희국 외 (공역) 발효식품예찬, 동심방 출판사 (2013) 변희국외 (공역) 수산발효식품의 제조 및 맛, 동심방 출판사 (2013) 변희국외 (공역) 오징어의 이용, 동심방 출판사 (2013) 변희국외 (공저) 해양과학 총서2 : 바다의 먹거리와 건강 (2012) Lee J.K., J.K. Jeon, S.K. Kim, H.G. Byun. Chapter 4. Characterization of bioactive peptides obtained from marine invertebrates. In Advances in Food and Nutrition Research V.65, Marine Medicinal Foods: Implications and Applications - Animals and Microbes, p.47-72, Ed. Se-Kwon Kim, Elsevier Inc. (2012) 변희국외 20명 (공역) 유기화학입문(제4판), 자유아카데미 출판사 (2011) 변희국외 17명 (공역) 대학화학의 기초(제13판), 자유아카데미 출판사 (2011) 변희국외 17명(공역) 대학화학의 기초(제12판), 자유아카데미 출판사 (2008) 변희국외 17명 (공저) 해양생명공학개론, 도서출판평화인쇄사(2007) Byun, H.G., P.J. Park, W.K. Jung, J.Y. Je and Se-kwon Kim, Chitin and its oligosaccharides as beta-secretase inhibitor, In Advances in Chitin Science, Volume VIII, p.101-103, ed. Henryk Struszczyk, Martin G. Peter, Alain domard, Henryk Pospieszny, ESUS, Poland 2005) Byun, H.G., P.J. Park, and Se-kwon Kim, Emulsion properties of carboxymethylchitin, In Chitosan in Pharmacy and Chemistry, p.193-198, ed R.A.A. Muzzarelli and C. Muzzarelli, ATEC, Italy (2002) Park, P.J., H.G. Byun and S.K. Kim, Free radical scavenging activities of chitosan oligosaccharides produced by bioreactor. Chitin Enzymology, p.437, R.A.A. Muzzarelli ed. Atec. Italy (2001) Byun, H.G. et al., Subacute oral toxicity of chitosan oligosaccharide on sprague dawley rats, In: Uragami, T., K. Kurita and T. Fukamizo (eds.), Chitin and Chitosan-Chitin and Chitosan in Life Science, Kodansha Scientific Ltd. Tokyo, Japan, p.276-277 (2001)

학회활동

한국수산과학회 한국생물공학회 한국해양바이오학회

한국키틴키토산학회 한국생명과학회 한국응용생명화학회

총설

변희국, 김세권, 해양바이오산업의 동향 및 전망, 식품산업과 영양 10(2), 32-39 (2005). 변희국, 김세권, 해조류의 생리활성 및 건강기능성 소재개발, 수산연구 22호 1-10 (2005). 변희국, 기능성 식품으로 어유가 버려지고 있다, 현대해양 383호, 56-58 (2002). 변희국, 김세권, 어유의 기능성 개선 및 그 응용, 수산연구 15호, 27-42 (2001). 김세권, 변희국, 수산식품분야에서의 막 분리기술 응용, 멤브레인 10(4), 163-174 (2000).

특허

변희국, 이정권. 클로렐라 에탄올 추출물내의 클로로필a의 함량을 증진시키는 방법. 출원번호 10-2014-0153563, 한국(2014. 11. 6) 변희국, 전중균, 김세권, 이정권. 클로렐라 추출물을 함유한 간질환의 예방 또는 치료용 조성물. 등록번호 10-1281858, 한국(2013. 6. 27) 변희국, 전중균, 이정권. 어류 껍질 유래의 펩타이드를 함유하는 항알쯔하이머 활성의 약학 조성물 및 건강기능식품. 등록번호 10-1297339, 한국 (2013. 8. 9) 변희국, 전중균, 이정권. 홍어 껍질 유래의 알쯔하이머 질병의 억제 또는 예방을 위한 조성물. 등록번호 10-1230650, 한국 (2013. 1. 3) 변희국, 전중균, 김세권, 박흠기, 이민수, 이정권, 동물플랑크톤 유래의 알츠하이머 질병의 억제 또는 예방을 위한 조성물 및 그 제조방법. 등록번호 10-1139415, 한국 (2012. 4. 17) 변희국. 김세권, 이정권, 윤지호, 해양동물플랑크톤 배양액 중의 대사산물을 유효성분으로 하는 간기능 개선 조성물 및 그 제조 방법. 등록번호 10-1090152, 한국 (2011.11.30) 변희국, 김세권, 이정권, 담수산 동물플랑크톤 유래의 항산화 및 항고혈압 펩타이드 조성물 및 그 제조방법. 출원번호 10-2008-0113681, 한국(2008.11.14) 변희국, 전중균, 김세권, 박흠기, 이정권, 해양동물플랑크톤 유래의 항산화 및 항고혈압 펩타이드 조성물. 등록번호 10-0943916, 한국(2010.2.17) 이배진, 노영란, 변희국, 정원교, 제재영, 아미노산 칼슘. 등록번호 10-2007- 0069123, 한국 (2007. 7. 2). 김문무, 김세권, 변희국, 감태추출물을 함유한 기질 금속단백질효소활성 억제용 조성물. 출원번호 10-2005-0107290, 한국 (2005. 11. 10). 김문무, 김세권, 변희국, 백발억제 및 흑모유발 촉진용 조성물. 등록번호 10-071272, 한국 (2007. 3. 22). No Y.R., B.J. Lee, H.G. Byun, J.Y. Je, W.K. Jung, Calcium binding amino acid, PCT/KR2005/003848 김세권, 이배진, 변희국, 정원교, 제재영, 칼슘이 결합된 펩티드 제조방법. 등록번호 10-0699047, 한국 (2007. 3. 16). 김세권, 변희국, 친리린, 김용태, 박표잠, 알쯔하이머성 치매질환 유발효소인 베타-세크리테아제의 저해제로서 키토산 및 그 올리고당. 출원번호 10-2002-0072431, 한국 (2002). 변희국, 정성윤, 박영태, 이원재, 김세권, 해양미생물의 대사산물에서 분리정제된 적조방제 물질. 출원번호 10-2002-0007582, 한국 (2002) 張 惠平, 卞熙國, 望月 正己, 志津里 芳一, 신규 항곰팡이 활성물질 및 그의 제조법. 출원번호 2000-59685, 일본 (2000). 김세권, 최광덕, 이원희, 변희국, 노호석, 이응호, 말쥐치 내장에서 유래된 콜라게나제 I. 등록번호 특1996-0006118, 한국 (1996). 김세권, 최광덕, 이원희, 변희국, 노호석, 이응호, 효소를 이용한 말쥐치의 탈피방법. 등록번호 특1995-0004565, 한국 (1995).

학술발표

1. Ko, S.C., J.K. Lee, H.G. Byun, and Y.J. Jeon, Angiotensin I Converting enzyme (ACE) inhibitory peptides identified from enzymatic digest of Styela plicata. 해양 바이오학회, 2009. 11. 20. 2. Lee, J.K., H.J. Lee, S.K. Kim, J.K. Jeon, and H.G. Byun, Purification and charterization of angiotention I converting enzyme inhibitory peptide from freshwater zooplankton, 해양 바이오학회, 2009. 11. 20. 3. Lee, J.K., H.J. Lee, S.K. Kim, J.K. Jeon, and H.G. Byun, Antioxidant activity of peptide isolated from freshwater rotifer protein hydrolysate, 해양 바이오학회, 2009. 11. 20. 4. Lee, J.K., H.J. Lee, S.K. Kim, J.K. Jeon, and H.G. Byun, Effect of matrix metalloproteinase-1 inhibitory activity peptide from skate skin protein, 해양 바이오학회, 2009. 11. 20. 5. Lee, J.K., H.J. Lee, J.K. Jeon, and H.G. Byun, Isolation and purification of angiotention I converting enzyme inhibitory peptide from skate skin protein, 해양 바이오학회, 2009. 11. 20. 6. Lee, H.J., J.K. Lee, S.K. Kim, J.K. Jeon, and H.G. Byun, Characterization of novel antioxidative peptide from sand eel, hypoptychus dybowskii, 해양 바이오학회, 2009. 11. 20. 7. Kim, H.W., K.W. Choi, J.K. Lee, J.K. Jeon, and H.G. Byun, Antioxidative effect of synthesized chitooligosaccharides by chemicall modifications, 해양 바이오학회, 2009. 11. 20. 8. Kim, H.W., K.W. Choi, J.K. Lee, J.K. Jeon, and H.G. Byun, Characterization and emusufying activity of carboxymethylchitosan, 해양 바이오학회, 2009. 11. 20. 9. Lee, J.K., H.G. Park, S.K. Kim, J.K. Jeon, and H.G. Byun, Enzymatic modification and characterization of lipid extracted from Rotifer, Brachionus rotundiformis, 해양 바이오학회, 2009. 11. 20. 10. Lee, J.K., H.J. Lee, S.K. Kim, J.K. Jeon, and H.G. Byun, Antioxidative activity of Rotifer peptide prepared by enzymatic hydrolysis, 해양 바이오학회, 2009. 11. 20. 11. Lee, J.K., H.J. Lee, S.K. Kim, J.K. Jeon, and H.G. Byun, Purification and characterization of angiotensin I coverting enzyme inhibitory peptides from the Rotifer, Brachionus rotundiformis, 해양 바이오학회, 2009. 11. 20. 12. Lee, J.K., H.J. Lee, H.G. Park, J.K. Jeon, and H.G. Byun, Purification and characterization of β-Secretase Inhibitory Peptides from Marine Zooplankton, 해양 바이오학회, 2009. 11. 20. 13. Park, S.H., D.M. Kim, B.H. Song, J.K. Jeon, and H.G. Byun, Novel angiotensin I coverting enzyme inhibitory peptides from the lance-fish, Hypoptychus dybowskii, 해양 바이오학회, 2009. 11. 20. 14. Cho, H., J.I. Choi, Y.H. Ryu, S.K. Kim, J.K. Jeon, and H.G. Byun, Isolation and characterization of an antioxidative peptide obtained from skate skin protein by enzymatic Hydrolisis, 해양 바이오학회, 2009. 11. 20. 15. Eom, T.K., C.S. Kong, H.G. Byun, and S.K. Kim, Enzymatic synthesis of low calorie oil from tuna oil affect adipogenic gene expressions in C57/BL6J mice, 해양 바이오학회, 2009. 11. 20. 16. Ahn, B., C.S. Kong, J.A. Kim, H.G. Byun, and S.K. Kim, Effects of carboxylmethyl-chitosan and -chitin on MMP inhibition and ROS scavenging in HT1080 human fibrosarcoma cells, 해양 바이오학회, 2009. 11. 20. 17. Cho, H., J.I. Choi, Y.H. Ryu, S.K. Kim, J.K. Jeon, and H.G. Byun, Isolation and characterization of an antioxidative peptide obtained from skate skin protein by enzymatic Hydrolisis, 한국수산과학연합회, 2009. 11. 12. 18. Lee, J.K., H.J. Lee, H.G. Park, and H.G. Byun, Purification and characterization of β-Secretase Inhibitory Peptides from Marine Zooplankton, 한국수산과학연합회, 2009. 11. 12. 19. Park, S.H., D.M. Kim, B.H. Song, and H.G. Byun, Novel angiotensin I coverting enzyme inhibitory peptides from the lance-fish, Hypoptychus dybowskii, 한국수산과학연합회, 2009. 11. 12. 20. Lee, J.K., H.J. Lee, S.K. Kim, and H.G. Byun, Antihypertensive effect of purified peptide from freshwater rotifer, Brachionus calyciflorus. 아시아태평양-국제펩타이드학회, 2009. 11. 8. 21. Lee. H.J., J.K. Lee, S.K. Kim, and H.G. Byun, Isolation and characterization of antioxidative peptide from sand eel, Hypoptychus dybowskii protein, 아시아태평양-국제펩타이드학회, 2009. 11. 8. 22. Lee, J.K., H.J. Lee, S.K. Kim, and H.G. Byun, A novel angiotensin I coverting enzyme (ACE) inhibition peptide from skate skin protein, 아시아태평양-국제펩타이드학회, 2009. 11. 8. 23. Lee, J.K., H.J. Lee, S.K. Kim, and H.G. Byun, Purification and characterization of angiotensin I coverting enzyme inhibitory peptides from the rotifer, Brachionus rotundiformis, 아시아태평양-국제펩타이드학회, 2009. 11. 8. 24. Lee, J.K., H.J. Lee, S.K. Kim, and H.G. Byun, Antioxidant Activity of Rotifer Peptide Prepared by Enzymatic hydrolysis, 아시아태평양-국제펩타이드학회, 2009. 11. 8. 25. Lee, J.K., H.J. Lee, S.K. Kim, and H.G. Byun, Free Radical Scavenging Activity of Purified Peptide from Freshwater Rotifer. 아시아태평양-국제펩타이드학회, 2009. 11. 8. 26. Lee, J.K., H.J. Lee, S.K. Kim, and H.G. Byun, Matrix Metalloproteinase-1 Inhibitory Activity of Peptie Purified from Skate Skin. 아시아태평양-국제펩타이드학회, 2009. 11. 8. 27. Lee, J.K., H.J. Lee, S. Hong, and H.G. Byun, Effect of Matrix Metalloproteinase-1 inhibitory Activity Peptide from Skate Skin Protein. 한국식품영양과학회, 2009. 11. 4. 28. Lee, J.K., H.J. Lee, J.K. Jeon, and H.G. Byun, Isolation and Purification of Angiotensin I Converting Enzyme Inhibitory Peptide from Skate Skin Protein. 한국식품영양과학회, 2009. 11. 4. 29. Lee, H.J., J.K. Lee, J.K. Jeon, and H.G. Byun, Effect of Antioxidant Peptide Obtained from Dybowskii Sand Eel by Enzymatic Hydrolysis. 한국식품영양과학회, 2009. 11. 4. 30. Lee, J.K., H.J. Lee, H.G. Park, and H.G. Byun, Purificaition and Characterization of Angiotensin I Converting Enzyme Inhibitory Peptide from Freshwater Zooplankton. 한국식품영양과학회, 2009. 11. 4. 31. Lee, J.K., H.J. Lee, S. Hong, and H.G. Byun, Antioxidant Activitiy of Peptide Isolated from Freshwater Rotifer Protein Hydrolysate. 한국식품영양과학회, 2009. 11. 4. 32. Ahn, B., C.S. Kong, J.A. Kim, H.G. Byun, and S.K. Kim, Effect of carboxymethyl-chitosan and -chitin on MMP inhibition related with ROS scavenging in HT1080 human fibrosarcoma cells. 한국분자·세포생물학회. 2009. 10. 15. 33. Kong, C.S., J.A. Kim, B. Ahn, H.G Byun, and S.K Kim, Effect of carboxymethyl-chitosan and -chitin on MMP inhibition related with ROS scavenging in HT1080 human fibrosarcoma cells. International Conference and Exhibition on Nutraceuticals and Functional Foods (ISNFF). 2009. 10.31 34. Ahn, B., C.S. Kong, J.A. Kim, H.G. Byun, and S.K. Kim, Effect of carboxymethyl-chitosan and -chitin on MMP inhibition related with ROS scavenging in HT1080 human fibrosarcoma cells. 대한생화학분자생물학회. 2009. 10. 29. 35. 공창숙, 변희국, 김세권, Antibeisty effect of carboxymethylated chitin in 3T3-L1 adipocytes via AMPK signal pathway. 한국키틴키토산 학회. 2009. 9.17. 36. Lee, S.J., E.K. Kim, J.W. Hwang, H.J. K, H.J. Oh, B.O. Lim, H.G. Byun, and P.J. Park, Antioxidative Enzyme Activities in Liver of Rats Fed High Fat Diet from Chitooligosaccharides. 한국키틴키토산학회. 2009. 9. 17. 37. Hwang, J.W., S.J. Lee, H.J. Oh, H.J. Kwon, E.K. Kim, H.G. Byun, and P.J. Park. 한국키틴키토산학회. 2009. 9. 17. 38. 안별님, 김정애, 공창숙, 변희국, 김세권, Effects of carboxymethyl-chitosan and -chitin on MMP expression and ROS scavenging in HT1080 human fibrosarcoma cells. 한국키틴키토산 학회. 2009. 9. 17. 39. Kong, C.S., J.A. Kim, T.K. Eom, H.G Byun, and S.K Kim, Carboxymethylated chitin inhibits adipocyte differentiation of 3T3-L1 preadiocytes via activating AMPK signal pathway. International Confernece on Chitin and Chitosan & Asia-Pacific Chitin and Chitosan Syposium. 2009 9. 6. 40. Kong, C.S., J.A. Kim, B. Ahn, T.K. Eom, H.G Byun, and S.K Kim. Effects of carboxymethyl-chitosan and chitin on ROS scavenging and MMP expression in HT1080 human fibrosarcoma cells. International Confernece on Chitin and Chitosan & Asia-Pacific Chitin and Chitosan Syposium. 2009 9. 6. 41. Kong, C.S., J.A. Kim, B. Ahn, T.K. Eom, H.G Byun, and S.K Kim. Effects of carboxymethyl-chitosan and -chitin on MMP inhibition related with ROS scavenging in HT1080 human fibrosarcoma cells. Federation of European Biochemical Societies. 2009. 7. 4. 42. Kong, C.S., J.A. Kim, B. Ahn, T.K. Eom, H.G Byun, N.Y. Yoon, and S.K Kim. Effects of carboxymethyl-chitosan and chitin on ROS scavenging and MMP expression in HT1080 human fibrosarcoma cells. Marine Biotechnology, 2009. 5. 30. 43. Eom, T.K., C.S. Kong, H.G. Byun, S.K. Kim, Enzymatic synthesis of low calorie oil from tuna oil affect adipogenic gene expression in C57/BL6J mice. 한국생물공학회. 2009. 4 9. 44. Kim. J.A., C.S. Kong, B. Ahn, T.K Eom, H.G. Byun, S.K. Kim. Effects of carboxymethyl-chitosan and -chitin on MMP inhibition related with ROS scavenging in HT1080 human fibrosarcoma cells. 한국생물공학회. 2009. 4. 9. 45. Jung, D.M., J.M. You, S.E. Kim, J.K. Lee, and H.G. Byun, Isolation and Purification of Matrix Metalloproteinase-1 Inhibitory Activity Peptide from Skate Skin. 한국해양바이오학회, 2008. 11. 27. 46. Lee, H. J., E.W. Son, J.K. Lee, and H.G. Byun, Purification and Characterization of an Antioxidative Peptide Obtained from Freshwater Zooplankton. 한국해양바이오학회, 2008. 11. 27. 47. Jeon, C.J., H.J. Kim, J.K. Lee, and H.G. Byun, Purification and Characterization of ACE Inhibitory Peptides from the Freshwater Zooplankton. 한국해양바이오학회, 2008. 11. 27. 48. Characterization of extracted fatty acids from marine zooplankton by lipase-catalyzed hydrolysis. 한국수산학회, 2008. 11. 13. 49. Kim, H.W., K.W. Choi, J.K. Lee, and H.G. Byun. Preparation and Characterization of Emulisions using Carboxymethylchitosan, 한국수산학회, 2008. 11. 13. 50. Lee, J.K., H.G. Park, S.K. Kim, and H.G. Byun, Purification and Characterization of Angiotensin I Converting Enzyme Inhibitory Peptides from the Rotifer, Brachionus calyciflorus. 한국수산학회, 2008. 11. 13. 51. Yun, J.H., J.K. Lee, H.G. Park, S.K. Kim, and H.G. Byun, Purification and Characterization of Antioxidative Peptide Obtained from Freshwater Rotifer Protein by Enzymatic Hydrolysis. 한국수산학회, 2008. 11. 13. 52. Jung, D.M., J.M. You, S.E. Kim, J.K. Lee, and H.G. Byun, Matrix Metalloproteinase-1 Inhibitory Activity of Peptide Purified from Skate Skin, 한국수산학회, 2008. 11. 13. 53. Kim, H.W., J.K. Lee, and H.G. Byun, Antioxidant Activity of Carboxymethyl Chitooligosaccharides. 한국수산학회, 2008. 11. 13. 54. Lee, H.J., E.W. Son, J.K. Lee, and H.G. Byun, Purification and Characterization of an Antioxidative Peptide Obtained from Freshwater Rotifer Protein by Enzymatic Hydrolysis. 한국생물공학회, 2008. 10. 6. 55. Jeon, C.J., H.J. Kim, J.K. Lee, and H.G. Byun, Purification and Characterization of Angiotensin I Converting Enzyme Inhibitory Peptides from the Rotifer, Brachionus calyciflorus. 한국생물공학회, 2008. 10. 6. 56. Kim, H.W., K.W. Choi, J.K. Lee, and H.G. Byun, Antioxidant Activity of Carboxymethyl Chitooligosaccharides. 한국생물공학회, 2008. 10. 6. 57. Kim, H.W., K.W. Choi, J.K. Lee, and H.G. Byun, Preparation and Characterization of Emulisions Using Carboxymethylchitosan. 한국생물공학회, 2008. 10. 6. 58. Kim, H.W., K.W. Choi, J.K. Lee, and H.G. Byun, Characterization and Emusufying activity of Carboxymethylchitosan. 한국키틴키토산학회, 2008. 9. 25. 59. Kim, H.W., K.W. Choi, J.K. Lee, and H.G. Byun, Antioxidative Effect of Synthesized Chitooligosaccharides by Chemical Modifications. 한국키틴키토산학회, 2008. 9. 25 60. Lee, J.K., H.J. Wo, J.K. Jeon, S.K. Kim, and H.G. Byun, Purification and Characterization of Angiotensin I Converting Enzyme Inhibitory Peptides from the Rotifer, Brachionus rotundiformis, 한국해양바이오학회, 2007. 11. 30. 61. Yun, J.K., J.S. Oh, S.H. Hong, and H.G. Byun, Purification and Characterization of an Antioxidative Peptide Obtained from Rotifer Protein by Enzymatic Hydrolysis.한국해양바이오학회, 2007. 11. 30. 62. Kim, H.J., N.B. Choi, J.K. Jeon, and H.G. Byun, Purification and characterization of Bioactive Peptide Purified from Skate Skin.한국해양바이오학회, 2007. 11. 30. 63. Yun, J.H., J.S. Oh, S.H. Hong, S.K. Kim, and H.G. Byun, Purification and Characterization of an Antioxidative Peptide Obtained from Rotifer Protein by Enzymatic Hydrolysis. 한국생물공학회, 2007. 10. 18 64. Kim, H.J., N.B. Choi, J.K. Jeon, and H.G. Byun, Purification and characterization of Bioactive Peptide Purified from Skate Skin. 한국생물공학회, 2007. 10. 18 65. Lee, J.K., H.J. Wo, J.K. Jeon, S.K. Kim, and H.G. Byun, Purification and Characterization of Angiotensin I Converting Enzyme Inhibitory Peptides from the Rotifer, Brachionus rotundiformis.한국생물공학회, 2007. 10. 18. 66. Kim, H.G., H.K. Park, H.G. Park, S.K. Kim, and H.G. Byun, Enzymatic Modification and Characterization of Lipid Extracted from Rotifer, Brachionus rotundiformis. 한국생물공학회, 2007. 10. 18. 67. Qian, Z.J., S.H. Lee, H.G. Byun, and S.K. Kim, Antihypertensive effect of a novel angiotensin I-converting enzyme inhibitory peptide from bigeye tuna (Thunnus obesus) dark muscle in spontaneously hypertensive rats. 한국수산학회, 2007. 5. 18. 68. Qian, Z.J., J.Y. Je, H.G. Byun, and S.K. Kim, Purification and Characterization of an antioxidant peptide obtained from tuna backbone protein by enzymatic hydrolysis. 한국해양바이오학회, 2006. 11. 17. 69. Qian, Z.J., J.Y. Je, H.G. Byun, and S.K. Kim, Purification and Characterization of an antioxidant peptide from gastrointestinal enzymatic digestion of bigeye tuna (Thunnus obesus) dark muscle. 한국해양바이오학회, 2006. 11. 17. 70. Qian, Z.J., W.K. Jung, H.G. Byun, and S.K. Kim, Purification and Characterization of an antioxidant peptide derived from oyster, Crassostrea gigas by gastro-intestinal digestion. 한국해양바이오학회, 2006. 11. 17. 71. Qian, Z.J., W.K. Jung, H.G. Byun, and S.K. Kim, Free Radical Scavenging Activityn of a Novel Antioxidative Peptide Isolated from in vitro Gastrointestinal Digests of Mytilus coruscus. 한국해양바이오학회, 2006. 11. 17. 72. Shon, T.K., H.G. Byun, W.K. Jung, M.M. Kim, and S.K. Kim, Chemo-Enzymatic Synthesis Lysoposphatidylcholine and Cytotoxic Activity in Various Human Cancer Cell line. 한국해양바이오학회, 2006. 11. 17. 73. Eom, T.K., H.G. Byun, W.K. Jung, M.M. Kim, and S.K. Kim, Chemo-Enzymatic Synthesis lysoposphatidylcholine and Cytotoxic Activity in Various Human Cancer Cell line. 대한생화학분자생물학, 2006. 5. 25. 74. Eom, T.K., H.G. Byun, W.K. Jung, and S.K. Kim, Synthesis and Anti-cancer effect of Monoacylglyceride and their Derivatives from Fish Oil, using Chemo-Enzymatic Methods. 한국수산학회, 2006. 5. 19. 75. Eom, T.K., H.G. Byun, W.K. Jung, and S.K. Kim, Solvent-free Lipase Catalyzed Synthesis of Diacylglycerol from Tuna Oil. 해양생물공학회, 2006. 5. 10 76. Je, J.Y., H.G. Byun, and S.K. Kim, Antimicrobial action of chitin and chitosan derivatives. Asia-Pacific Chitin and Chitosan Symposium, 2006. 4. 23.

해양생물신소재공학연구실

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연구 분야 소개

- 해양생물자원 유래의 항고혈압 소재 개발 - 해양생물자원 유래의 항산화성 소재 개발 - 해양생물자원 유래의 항암 및 항치매 소재 개발 - 해양미생물 유래의 신기능성 생물신소재 개발 - 해양천연물의 분리정제 및 구조해석 - Lipase에 의한 어유의 기능성 개선 - Membrane bioreactor를 이용한 연속적 대량 생산 기술

주요 활동

  • 생리활성 펩타이드 연구

    생리활성 펩타이드 연구

    해양 생물, 미이용 생물 및 수산 가공 부산물로부터 생리활성 펩타이드 연구

  • 생리활성 메커니즘 규명

    생리활성 메커니즘 규명

    생리활성물질의 세포내에서 효능 및 작용기작 탐색

  • 기능성 소재의 산업화 기술

    기능성 소재의 산업화 기술

    생물전환기술을 이용한 기능성 신소재 대량생산 기술 구축

  • 분리정제 기술

    분리정제 기술

    막분리 및 크로마토그래피를 이용한 생리활성 물질 분리 및 정제